Dedifferentiated liposarcoma lacks effective IGF-1→PPAR-γ adipogenic signaling due to epigenetic silencing of PPAR-γ2, with ...

TNBCs rely on fatty acid oxidization (FAO) to fuel tumor growth by breaking down surrounding adipose tissue through lipolysis. Gap junctions, particularly involving GJB3 and connexin 31 (Cx31), ...

Researchers led by the University of California, San Francisco (UCSF), report a new approach that deprived tumors of nutrition in cancer models, and may one day lead to a new approach that can be ...

In the ongoing effort to find better ways to fight cancer, scientists have developed a creative approach that uses the body’s own fat cells in a surprising way. Instead of allowing tumors to consume ...

University of Kentucky Markey Cancer Center researchers have identified a protein that could be a promising treatment target for obesity-related breast cancer. Subscribe to our newsletter for the ...

CLD-201, an allogeneic adipose stem-cell loaded oncolytic virus, received FDA fast track designation for soft tissue sarcoma treatment. Fast track designation expedites drug development and review for ...

In a striking new study, the anti-obesity drug tirzepatide, known as Mounjaro and Zepbound, not only triggered significant weight loss in obese mice but also slashed breast cancer tumor growth. The ...

The anti-obesity medication tirzepatide, marketed as Mounjaro for diabetes and Zepbound for obesity, reduced obesity-associated breast cancer growth in a mouse model, according to a study being ...

Patients with triple-negative breast cancer (TNBC) have more aggressive, invasive tumors and fewer treatment options than other kinds of breast cancers. TNBC tumors use fatty acid oxidation as a key ...

Tumor growth is associated with profound metabolic and neurochemical alterations, which can lead to the onset of anorexia−cachexia syndrome. Anorexia is defined as the loss of the desire to eat, while ...